Here are some scenario-based multiple choice questions about familial hypercholesterolemia
1) John is a 35-year-old man who has a family history of early heart disease. He presents to his doctor with high cholesterol levels. His doctor suspects familial hypercholesterolemia. What is the most likely pattern of inheritance for this condition?
a) Autosomal dominant
b) Autosomal recessive
c) X-linked dominant
d) X-linked recessive
2) Sarah is a 25-year-old woman who has a family history of high cholesterol levels and heart disease. She is found to have very high levels of LDL cholesterol on blood tests. What is the most likely diagnosis?
a) Familial hypercholesterolemia
b) Polygenic hypercholesterolemia
c) Secondary hypercholesterolemia
d) Hypoalphalipoproteinemia
3) Mark is a 40-year-old man who has been diagnosed with familial hypercholesterolemia. His doctor recommends that he start taking a statin medication to lower his cholesterol levels. What is the mechanism of action of statins?
a) They increase the production of HDL cholesterol
b) They decrease the absorption of cholesterol from the intestines
c) They decrease the synthesis of cholesterol in the liver
d) They increase the clearance of LDL cholesterol from the bloodstream
4) Jennifer is a 30-year-old woman who has been diagnosed with familial hypercholesterolemia. Her doctor recommends that she follow a low-fat diet and exercise regularly. What is the rationale behind this recommendation?
a) It will increase the production of HDL cholesterol
b) It will decrease the absorption of cholesterol from the intestines
c) It will decrease the synthesis of cholesterol in the liver
d) It will decrease the circulating levels of LDL cholesterol
5) Tom is a 50-year-old man who has been diagnosed with familial hypercholesterolemia. Despite lifestyle modifications and statin therapy, his LDL cholesterol levels remain very high. What is the next step in management?
a) Add a bile acid sequestrant medication
b) Add a fibrate medication
c) Add a PCSK9 inhibitor medication
d) Add niacin (vitamin B3) supplementation
Answers
1) a) Autosomal dominant
2) a) Familial hypercholesterolemia
3) c) They decrease the synthesis of cholesterol in the liver
4) d) It will decrease the circulating levels of LDL cholesterol
5) c) Add a PCSK9 inhibitor medication
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